Welcome to the Department
of Pathology and Molecular Medicine
This is an exciting time of growth, innovation and success for our Department which is uniquely placed at the interfaces between basic biomedical sciences, clinical laboratory services and the emerging field of personalized molecular medicine. Our clinical faculty membership has been rejuvenated and expanded over the last two years with no less than 10 success recruitments, 4 of which represent newly funded positions. We are also looking to expand our basic science programs and are actively recruiting a Tier 1 Bioinformatician and also a translational basic science researcher.
Posted 2018 February 21
From /www.queensu.ca/gazette/stories/ unraveling-mysteries-blood
Queen's University researcher Paula James has revealed women who are carriers of hemophilia A, an inherited bleeding disorder, experience abnormal bleeding in about 30 per cent of cases. Dr. James is working to unravel the mystery as to why this abnormal bleeding, including nosebleeds, heavy periods, and bleeding following childbirth, occurs.
To define abnormal bleeding, Dr. James used a bleeding score where higher numbers represent more intense bleeding.
"It's long been assumed that women who carry this gene don't have bleeding symptoms but we now know that isn't true," says Dr James, who also works as a clinician-scientist at Kingston Health Sciences Research Institute. "Some patients have low levels of clotting Factor FVIII in their blood, and for those that don't, there must be other contributing factors. It's a challenging problem because it has led to their bleeding symptoms being dismissed and not treated properly."
Her team has discovered that women who are carriers of hemophilia A respond differently to the stresses that cause bleeding - even those who have normal levels of Factor VIII in their blood.
"Normally when we're injured or cut or stressed in other ways, a number of the elements that help our blood clot go up. However, we thought that it might not work that way in these women," says Dr. James. "So what other things could be happening within someone's body that would make them at risk for bleeding?"
To find out, Dr. James and her group compared levels of Factor VIII circulating in the blood levels of 17 women who are carriers of hemophilia A with those of seven normal control patients. The volunteers' blood was tested before and after being treated with Desmopressin, a drug that causes an immediate increase in clotting factor levels that mimics the way the body responds to being cut or injured.
The researchers were looking to see whether the women's response to the drug was related to how much Factor VIII was already in their blood. "We wondered whether a person's response was only dependent on where they were starting from using a baseline," James says. "That turned out not to be the case."
The study was published in Blood Advances.
Posted 2018 February 20
Congratulations to Coach Scott Davey and the Queen's Gaels, who were crowned the 2019 OUA Women's Curling Champions on Monday as the five-day championships came to a close at the KW Granite Club.
In an exciting final day that saw both gold medal games come down to the final end, the Gaels brought the OUA banner back to Queen's for the first time since 1994.
"We're really excited to be able to bring the banner home for Queen's," says Gaels skip Mary Fay. "It's really nice to go to a school and you're really proud to be a part of something so to be able to bring that home for them is really exciting."
In the women's game, like they had done for the majority of the week, the Gaels were ruthless in their efficiency. Controlling the game with wide-open play, the Fay foursome scored two in the second and fourth ends to lead 4-1.
Laurentian managed to pull themselves back into the contest with singles in both the fifth and sixth ends but Queen's responded with two more in the seventh to give them a three-point cushion coming home.
The Gaels then ran Laurentian out of rocks to secure the 6-4 victory.
Posted 2018 January 15
The Canadian Resident Matching Service (CaRMS) is a national, independent, not-for-profit, fee-for-service organization that provides a fair, objective and transparent application and matching service for medical training throughout Canada.
Residency Applicants will be visiting the Department through the week of January 21-25, 2019.
Posted 2018 December 12
Congratulations to Dr. Victoria Hoskin (center, red jacket) who was one of 10 trainees from 116 abstracts selected to give oral presentations at the Terry Fox Research Institute Ontario Node Research Symposium in Toronto on Dec 10, 2018. Victoria's presentation "Targeting the cytoskeleton protein ezrin sensitizes metastatic breast cancer cells to chemotherapy treatment" described her Ontario Medical Pathology Research Network funded project supervised by Drs. Sonal Varma and Peter Greer.
[see more Spotlight Archive]...
Monday 2019 Feb 25
8:30-9:30 Autopsy Conference - CANCELLED
11:30-12:20 Path 310 - Walter Light Auditorium - Acute Leukemia - M. Rauh
1:00-2:00 Hematopathology Review - Richardson Lab Rm. 107
2:30-5:20 Canc 440 - Richardson Lab Room 101- L. Mulligan & D. Berman
Tuesday 2019 February 26
9:00-10:00 Neuropathology Conference - Autopsy Conference Rm.
1:30-2:20 Path 310 - Walter Light Auditorium - Acute Leukemia - D. Good
2:00-3:00 GI & Liver Conference - Multihead Microscope Rm.
4:00-5:00 Path 830/930 Dept Research Seminar - Richardson Lab Amphitheatre - Palak Patel, PhD - "Diagnostic and prognostic biomarkers for prostate cancer"
Wednesday 2019 Feb 27
9:00-9:55 Micro (Peds) - Richardson Lab Rm. 102 - Dr. A. Wang
10:00-10:55 Soft Tissue - Adult - Multihead Microscope Rm. - Dr. S. SenGupta
11:00-11:55 Research Progress - Richardson Lab Rm. 102 - Dr. N. Renwick
11:30-2:20 Path 430/826 - Richardson Lab Room 101 - Leukemia/Lymphoma - M. Rauh & G. Quest
Thursday 2019 Feb 28
11:30-12:30 Grand Rounds - CANCELLED
12:30-1:20 Path 310 - Walter Light Auditorium - ILM2 - M. Bowman
4:00-5:00 QCRI Seminar Series - QCRI Room 100/102 - Genitourinary Translational Research Team Presentation - "A pipeline for predictive biomarkers in
bladder cancer" - Presenters: David Berman, Paco Vera Badillo, Madhuri Koti, Chelsea Jackson
Friday 2019 March 01 - Last date to drop winter term classes without academic penalty
9:00-9:30 Gross Rounds - Gross Room - Dr. A. Wang
1:30-2:30 Hematopathology Morphology Round - Autopsy Conference Rm.
Friday 2019 April 05 - Winter Term Classes end
Announcements / Notices
2018 November 16
Welcome to the Department Dr. Yanping Gong to the positions of Assistant Professor at Queenâs University and Attending Staff Pathologist at the Kingston Health Sciences Centre with a focus in clinical pathology and perinatal pathology, effective 2018 Nov 19
2018 Oct 18
The Dr. M. Daria Haust Pathology Studentship shall be used each year towards either funding one or two studentships for Queen's medical students in the summer immediately after their first or second year of medical school, to undertake research, clinical work or academic endeavours within the Department of
Pathology and Molecular MedÃcine at eueen's University. Information and Application
2018 June 28
Welcome to the Department Dr. Yun Huang, Clinical Biochemist and Dr. Tao Wang, Pathologist, as of 2018 July 03.
Faculty Appointment in Translational Pathology/Molecular Medicine
Queenâs University, Kingston, Ontario, Canada
The Department of Pathology and Molecular Medicine at Queenâs University invites applications
from internationally recognized scientists whose research is congruent with the objective of
building an outstanding program in innovative translational research linking diagnostic pathology
and clinical management. The successful applicant will be eligible for a tenured appointment at
the rank of Associate Professor or Professor and is expected to participate in education and
supervision/mentoring of trainees at all levels. Salary will be commensurate with qualifications and
experience. The preferred start date for this position is September 1, 2019.
Posted 2019 January 31
Tier 2 Canada Research Chair in Biomedical Metabolomics
The Faculty of Health Sciences at Queenâs University invites applications for a tenure-track faculty position as a Tier 2 Canada Research Chair in Biomedical Metabolomics, with an anticipated starting date of July 1, 2019.
Posted 2018 November 08
Complete information here
Tier 2 Canada Research Chair in Microbiome Research
The Faculty of Health Sciences at Queenâs University invites applications for a tenuretrack
faculty position as a Tier 2 Canada Research Chair in Microbiome Research, with
an anticipated starting date of July 1, 2019.
Posted 2018 November 08
Complete information here
Post-doctoral Research Fellowship
Influence of the Host Microbiome on Factor VIII Immunogenicity
A post-doctoral research fellow position is available as part of a 5-year NIH NHLBI-funded project aimed at furthering our understanding of the role of the gut microbiome as a determinant of factor VIII (FVIII) immunogenicity. Funds to initiate these studies have just become available.
Applications will be taken until position filled.
Posted 2018 October 4
Complete information here
Welcome to the Queen's Laboratory for Molecular Pathology
The QLMP is part of the Department of Pathology and Molecular Medicine at Queen's University, Kingston, Ontario. The QLMP provides rapid and economic advanced pathology services to researchers, students, clinicians, and private sector groups. The QLMP promotes productive interactions between scientists, clinicians, pathologists, and others by supporting research projects of common interest.
The (269) 722-1498 offers a wide array of services including:
TMA design and construction
Whole slide scanning
Customized immunohistochemistry and immunofluoroscence
Image analysis tools
Secure web database access and storage
The Canadian National
Inherited Bleeding Disorder
Providing molecular diagnostic services to the Canadian inherited bleeding disorder community.